Abstract
S3 is generally audible in normal children and young adults but disappears with maturation. Disappearance of the physiologic S3 has been correlated with a decrease in the rate of early diastolic left ventricular filling and subsequent deceleration of inflow, possibly resulting from maturation-associated relative left ventricular hypertrophy.1 We examined the association of the disappearance of the physiologic S3 to changes in left ventricular diastolic function with aging.