Meta-analysis of genome-wide association data identifies two loci influencing age at menarche

John R.B. Perry; Lisette Stolk; Nora Franceschini; Kathryn L. Lunetta; Guangju Zhai; Patrick F. McArdle; Albert V. Smith; Thor Aspelund; Stefania Bandinelli; Eric Boerwinkle; Lynn Cherkas; Gudny Eiriksdottir; Karol Estrada; Luigi Ferrucci; Aaron R. Folsom; Melissa Garcia; Vilmundur Gudnason; Albert Hofman; David Karasik; Douglas P. Kiel; Lenore J. Launer; Joyce Van Meurs; Michael A. Nalls; Fernando Rivadeneira; Alan R. Shuldiner; Andrew Singleton; Nicole Soranzo; Toshiko Tanaka; Jenny A. Visser; Michael N. Weedon; Scott G. Wilson; Vivian Zhuang; Elizabeth A. Streeten; Tamara B. Harris; Anna Murray; Tim D. Spector; Ellen W. Demerath; André G. Uitterlinden; Joanne M. Murabito

doi:10.1038/ng.386

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Meta-analysis of genome-wide association data identifies two loci influencing age at menarche

Journal article

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Meta-analysis of genome-wide association data identifies two loci influencing age at menarche

John R.B. Perry, Lisette Stolk, Nora Franceschini, Kathryn L. Lunetta, Guangju Zhai, Patrick F. McArdle, Albert V. Smith, Thor Aspelund, Stefania Bandinelli, Eric Boerwinkle, …

Nature genetics, Vol.41(6), pp.648-650

06/2009

DOI: https://doi.org/10.1038/ng.386

PMCID: PMC2942986

PMID: 19448620

Abstract

Genetics

We conducted a meta-analysis of genome-wide association data to detect genes influencing age at menarche in 17,510 women. The strongest signal was at 9q31.2 (P = 1.7 × 10 9), where the nearest genes include TMEM38B, FKTN, FSD1L, TAL2 and ZNF462. The next best signal was near the LIN28B gene (rs7759938; P = 7.0 × 10 9), which also influences adult height. We provide the first evidence for common genetic variants influencing female sexual maturation.

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Title: Meta-analysis of genome-wide association data identifies two loci influencing age at menarche
Creators: John R.B. Perry (Author) - Peninsula Medical School Universities of Exeter and Plymouth
Lisette Stolk (Author) - Erasmus University Rotterdam;Netherlands Genomics Initiative (NGI)
Nora Franceschini (Author) - University of North Carolina at Chapel Hill
Kathryn L. Lunetta (Author) - National Heart, Lung, and Blood Institute's The Framingham Heart Study;Boston University
Guangju Zhai (Author) - King's College London
Patrick F. McArdle (Author) - University of Maryland, Baltimore
Albert V. Smith (Author) - Icelandic Heart Association
Thor Aspelund (Author) - Icelandic Heart Association;University of Iceland
Stefania Bandinelli (Author) - Geriatric Unit
Eric Boerwinkle (Author) - University of Texas Health Science Center at Houston
Lynn Cherkas (Author) - King's College London
Gudny Eiriksdottir (Author) - Icelandic Heart Association
Karol Estrada (Author) - Erasmus University Rotterdam
Luigi Ferrucci (Author) - National Institutes of Health
Aaron R. Folsom (Author) - University of Minnesota Twin Cities
Melissa Garcia (Author) - National Institutes of Health
Vilmundur Gudnason (Author) - Icelandic Heart Association;University of Iceland
Albert Hofman (Author) - Erasmus University Rotterdam;Netherlands Genomics Initiative (NGI)
David Karasik (Author) - National Heart, Lung, and Blood Institute's The Framingham Heart Study;Harvard University
Douglas P. Kiel (Author) - National Heart, Lung, and Blood Institute's The Framingham Heart Study;Harvard University
Lenore J. Launer (Author) - National Institutes of Health
Joyce Van Meurs (Author) - Erasmus University Rotterdam;Netherlands Genomics Initiative (NGI)
Michael A. Nalls (Author) - National Institutes of Health
Fernando Rivadeneira (Author) - Erasmus University Rotterdam;Netherlands Genomics Initiative (NGI)
Alan R. Shuldiner (Author) - University of Maryland, Baltimore
Andrew Singleton (Author) - National Institutes of Health
Nicole Soranzo (Author) - King's College London;Wellcome Sanger Institute
Toshiko Tanaka (Author) - National Institutes of Health
Jenny A. Visser (Author) - Erasmus University Rotterdam
Michael N. Weedon (Author) - Peninsula Medical School Universities of Exeter and Plymouth
Scott G. Wilson (Author) - King's College London;University of Western Australia
Vivian Zhuang (Author) - Public Health
Elizabeth A. Streeten (Author) - University of Maryland, Baltimore
Tamara B. Harris (Author) - National Institutes of Health
Anna Murray (Author) - Peninsula Medical School Universities of Exeter and Plymouth
Tim D. Spector (Author) - King's College London
Ellen W. Demerath (Author) - University of Minnesota Twin Cities
André G. Uitterlinden (Author) - Erasmus University Rotterdam;Netherlands Genomics Initiative (NGI)
Joanne M. Murabito (Author) - National Heart, Lung, and Blood Institute's The Framingham Heart Study;Boston University
Additional links: Anon
Publication Details: Nature genetics, Vol.41(6), pp.648-650
Series: 41
Number of pages: 3
Identifiers: 991005929512402656
Academic Unit: Master Public Health
Language: English
Resource Type: Journal article

Meta-analysis of genome-wide association data identifies two loci influencing age at menarche

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