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Molecular mechanism for the production of multiple form of MM creatine kinase
Journal article

Molecular mechanism for the production of multiple form of MM creatine kinase

M. B. Perryman, J. D. Knell and R. Roberts
Experientia, Vol.40(11)
1984
DOI: https://doi.org/10.1007/BF01946672

Abstract

Creatine kinase, MM isoenzymes myocardium carboxypeptidase creatine kinase mm isoenzyme animal cell dog heart human human cell muscle priority journal Amino Acids Animal Carboxypeptidases Creatine Kinase Dogs Electrophoresis, Polyacrylamide Gel Lysine Lysine Carboxypeptidase Muscles Peptide Fragments Rabbits
Incubation of human, canine or rabbit MM creatine kinase with carboxypeptidase-N or B resulted in the production of 2 additional enzyme forms with increased anodal migration on polyacrylamide gels. The C-terminal amino acid of tissue MM creatine kinase from all 3 species was shown to be lysine, a specific substrate for carboxypeptidase-N and B. © 1984 Birkhäuser Verlag.

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