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Mpox in a Patient With a Signal Transducer and Activator of Transcription 1 Gain-of-Function Mutation
Journal article   Peer reviewed

Mpox in a Patient With a Signal Transducer and Activator of Transcription 1 Gain-of-Function Mutation

Jack W. McHugh, Eric O. Gomez, Omar M. Abu-Saleh, Cristina G. Corsini Campioli, Supavit Chesdachai, Saadiya Nazli, Nicholas T. Streck, Shama Cash-Goldwasser, Agam K. Rao, Michelle L. Meyer, …
Mayo Clinic Proceedings, Vol.100(3)
2025
DOI: https://doi.org/10.1016/j.mayocp.2024.11.022

Abstract

Fatal Outcome Female Gain of Function Mutation Humans Male STAT1 Transcription Factor cefazolin immunoglobulin immunoglobulin G immunoglobulin M STAT1 protein tecovirimat valaciclovir STAT1 protein STAT1 protein, human adult Article case report chronic mucocutaneous candidiasis clinical article computer assisted tomography exocytosis female gain of function mutation ground glass opacity human immune response immune system immunohistochemistry interstitial pneumonia intestine ischemia lower limb lumbar puncture methicillin susceptible Staphylococcus aureus molluscum contagiosum monkeypox necrosis polymerase chain reaction Pseudomonas aeruginosa respiratory failure reverse transcription polymerase chain reaction seizure septic shock splenectomy T lymphocyte ulcer Varicella zoster virus vulvovaginitis fatality genetics male
We report a case of mpox in a patient with a signal transducer and activator of transcription 1 gain-of-function mutation. Despite initial improvement with intravenous immune globulin and tecovirimat, severe symptoms developed and the patient died. This underscores the need for immune system optimization and effective virucidal treatments for mpox. © 2024 Mayo Foundation for Medical Education and Research

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