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Multifocal dysembryoplastic neuroepithelial tumours associated with refractory epilepsy
Journal article   Peer reviewed

Multifocal dysembryoplastic neuroepithelial tumours associated with refractory epilepsy

Andrew I. Yang, Ayaz M. Khawaja, Leo Ballester-Fuentes, Svetlana D. Pack, Ziedulla Abdullaev, Nicholas J. Patronas, Sara K. Inati, William H. Theodore, Martha M. Quezado and Kareem A. Zaghloul
Epileptic Disorders, Vol.16(3)
2014
DOI: https://doi.org/10.1684/epd.2014.0680

Abstract

Brain Neoplasms Epilepsy Humans Male Neoplasms, Neuroepithelial Seizures Temporal Lobe Young Adult Chiari malformation multi-focal tumor tumor-associated epilepsy anticonvulsive agent glial fibrillary acidic protein synaptophysin adult African American Arnold Chiari malformation Article brain surgery case report disease association disease course dysembryoplastic neuroepithelial tumor electroencephalography focal epilepsy histopathology human incidental finding male neuroepithelioma nuclear magnetic resonance imaging pathological anatomy surgical approach temporal lobe treatment outcome tumor growth tumor localization tumor volume young adult Arnold Chiari malformation article brain tumor epilepsy multi-focal tumor neuroepithelioma pathology seizure temporal lobe tumor-associated epilepsy
Dysembryoplastic neuroepithelial tumours (DNET) are a common cause of tumour-associated epilepsy, and are usually located in the temporal lobes. We present a case of multifocal DNETs in both infra- and supra-tentorial locations, in a 23-year-old man with a coincident Type I Chiari malformation, presenting with medically refractory focal seizures. The extensive anatomical distribution of the lesions suggests a genetic component in their tumourigenesis.

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