Mutant kras as a biomarker plays a favorable role in fl118-induced apoptosis, reactive oxygen species (Ros) production and modulation of survivin, mcl-1 and xiap in human bladder cancer

Sreevidya Santha; Xiang Ling; Ieman A.M. Aljahdali; Sailee S. Rasam; Xue Wang; Jianqun Liao; Jue Wang; Christos Fountzilas; Qingyong Li; Jun Qu; Fengzhi Li

doi:10.3390/cancers12113413

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Mutant kras as a biomarker plays a favorable role in fl118-induced apoptosis, reactive oxygen species (Ros) production and modulation of survivin, mcl-1 and xiap in human bladder cancer

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Mutant kras as a biomarker plays a favorable role in fl118-induced apoptosis, reactive oxygen species (Ros) production and modulation of survivin, mcl-1 and xiap in human bladder cancer

Sreevidya Santha, Xiang Ling, Ieman A.M. Aljahdali, Sailee S. Rasam, Xue Wang, Jianqun Liao, Jue Wang, Christos Fountzilas, Qingyong Li, Jun Qu, …

Cancers, Vol.12(11), pp.1-25

11/18/2020

DOI: https://doi.org/10.3390/cancers12113413

PMID: 33217967

Abstract

Apoptosis

Bladder cancer

FL118

Human bladder tumor mouse models

Mcl-1

Mutant Kras

Proteomics analysis

Reactive oxygen species (ROS)

Survivin

XIAP

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Title: Mutant kras as a biomarker plays a favorable role in fl118-induced apoptosis, reactive oxygen species (Ros) production and modulation of survivin, mcl-1 and xiap in human bladder cancer
Creators: Sreevidya Santha - Roswell Park Comprehensive Cancer Center
Xiang Ling - Canget BioTekpharma (United States)
Ieman A.M. Aljahdali - Roswell Park Comprehensive Cancer Center
Sailee S. Rasam - University at Buffalo, State University of New York
Xue Wang - Roswell Park Comprehensive Cancer Center
Jianqun Liao - Canget BioTekpharma (United States)
Jue Wang - University of Arizona
Christos Fountzilas - Roswell Park Comprehensive Cancer Center
Qingyong Li - Zhejiang University of Technology
Jun Qu - University at Buffalo, State University of New York
Fengzhi Li - Roswell Park Comprehensive Cancer Center
Publication Details: Cancers, Vol.12(11), pp.1-25
Number of pages: 25
Grant note: National Cancer Institute (http://data.elsevier.com/vocabulary/SciValFunders/100000054) P30CA016056 / National Institutes of Health (100000002) 20-65-FENG / Pancreatic Cancer Action Network (http://data.elsevier.com/vocabulary/SciValFunders/100001784) R44CA176937 / National Institutes of Health (100000002) National Cancer Institute (100000054) P30CA016056; R03CA182552; R21CA180764; R44CA176937 / National Institutes of Health (http://data.elsevier.com/vocabulary/SciValFunders/100000002) National Institutes of Health (http://data.elsevier.com/vocabulary/SciValFunders/100000002) R21CA180764 / National Institutes of Health (100000002) R03CA182552 / National Institutes of Health (100000002) Pancreatic Cancer Action Network (http://data.elsevier.com/vocabulary/SciValFunders/100001784)
Identifiers: 991006261915002656
Academic Unit: Internal Medicine
Language: English
Resource Type: Journal article