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PCSK9 inhibition-A new thrust in the prevention of heart disease: Genetics does it again
Journal article

PCSK9 inhibition-A new thrust in the prevention of heart disease: Genetics does it again

R. Roberts
Canadian Journal of Cardiology, Vol.29(8)
2013
DOI: https://doi.org/10.1016/j.cjca.2013.04.014

Abstract

3 hydroxy 3 methylglutaryl coenzyme A acetic acid derivative amino acid apolipoprotein E atorvastatin cholesterol glycoprotein hydroxymethylglutaryl coenzyme A reductase inhibitor insulin leptin low density lipoprotein cholesterol low density lipoprotein receptor monoclonal antibody protein pcsk 9 small interfering RNA unclassified drug very low density lipoprotein atherosclerosis cholesterol blood level cholesterol synthesis coenzyme coronary artery atherosclerosis coronary artery disease editorial endocytosis familial hypercholesterolemia gain of function mutation gene mutation genetic analysis genetic predisposition genotype heart disease heart infarction human hypercholesterolemia insulin resistance liver cell loss of function mutation protein binding protein degradation risk factor secondary prevention Apolipoproteins E Female Humans Lipids Male Proprotein Convertases Serine Endopeptidases

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