Abstract
Within an hour of receiving the dose, the child developed edema of the lips, along with massive dermal edema which initially involved the periorbital region and the face and later spread to involve the trunk and the limbs. [5] Nonsteroidal anti-inflammatory drug (NSAID including aspirin) use has a higher propensity to be associated with urticaria, angioedema, and pruritus caused by non-allergic reactions due to inhibition of isoform 1 of cyclooxygenase (COX 1).