Abstract
We conducted a prospective study examining the impact of a hospital-based PPI automatic therapeutic interchange program on patient-perceived clinical and humanistic outcomes. Patients talking omeprazole before being hospitalized were switched to the hospital's preferred PPI, lansoprazole; while those taking lansoprazole prior to hospitalization continued on lansoprazole on an inpatient basis. No differences were observed between the two patient groups with regard to demographics, GI symptom severity scores, or satisfaction or expectations associated with their inpatient PPI therapy at either admission or discharge (p > 0.05). A significant improvement in patient-perceived GI symptom severity was observed within each group from admission to discharge (p <0.01). Some 37% of patients whose medication was interchanged were unaware that this interchange occurred during their hospital stay. A hospital-based PPI therapeutic interchange program did not adversely affect patient-perceived outcomes of PPI therapy.