Abstract
When traditional therapies are unsuitable, revascularization becomes essential for managing posterior inferior cerebellar artery (PICA) or vertebral artery aneurysms. Notably, the PICA-PICA bypass has emerged as a promising option, overshadowing the occipital artery-PICA (OA-PICA) bypass. The objective was to compare the safety and efficacy of OA-PICA and PICA-PICA bypasses.
Following the Preferred Reporting Items for Systematic Reviews and Meta-Analysis guidelines, we conducted a systematic review and meta-analysis to evaluate the safety and efficacy of OA-PICA and PICA-PICA bypasses for treating posterior circulation aneurysms.
We analyzed 13 studies for the PICA-PICA bypass and 16 studies on the OA-PICA bypass, involving 84 and 110 patients, respectively. The median average follow-up for PICA-PICA bypass was 8 months (2–50.3 months), while for OA-PICA, it was 27.8 months (6–84 months). The patency rate for OA-PICA was 97% (95% confidence interval [CI]: 92%–100%) and 100% (95% CI: 95%–100%) for PICA-PICA. Complication rates were 29% (95% CI: 10%–47%) for OA-PICA and 12% (95% CI: 3%–21%) for PICA-PICA. Good clinical outcomes were observed in 71% (95% CI: 52%–90%) of OA-PICA patients and 87% (95% CI: 75%–100%) of PICA-PICA patients. Procedure-related mortality was 1% (95% CI: 0%–6%) for OA-PICA and 1% (95% CI: 0%–10%) for PICA-PICA.
Both procedures have demonstrated promising results in efficacy and safety. PICA-PICA exhibits slightly better patency rates, better clinical outcomes, and fewer complications, but with a lack of substantial follow-up and a smaller sample size. The choice between these procedures should be based on the surgeon's expertise and the patient's anatomy.
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