Dr. Mann served as a consultant for Novartis. Dr. Greene has received research support from Amgen, AztraZeneca, Bristol-Myers Squibb, Merck, and Novartis; and is a consultant for Amgen and Merck; is a member of the advisory boards of Amgen and Cytokinetics. Dr. Starling served as a consultant for Novartis; and is on the steering committee for the PARAGLIDE trial. Dr. Ambrosy has received research support from Novartis; and has received personal fees for the PIONEER-HF trial. Dr. Shah is an employee of Inova Heart and Vascular Institute; has received grant support from Merck, Abbott, Bayer, Medtronic, and Pulse CV; and is a consultant for NuPulse, Ortho Clinical Diagnostics, and Procyrion. Dr. Mahr is a consultant for Abbott, Medtronic, and Abiomed. Dr. Lewis has been a consultant for and received research support from Cytokinetics and Applied Therapeutics; and received research support from Amgen and AstraZeneca. Dr. Mohammed is a member of the advisory board for Pfizer; and has received research support from Cardiocell, Abbott, Actelion, Corvia, and Medtronic. Dr. Gilotra is a consultant for scPharmaceuticals. Dr. DeVore has received research support through his institution from the American Heart Association, Amgen, AstraZeneca, Bayer, Intra-Cellular Therapies, American Regent, National Heart, Lung, Blood Institute, Novartis, and Patient-Centered Outcomes Research Institute; and is a consultant for Novartis. Dr. Desvigne-Nickens is an employee of the National Heart, Lung, and Blood Institute; and is a consultant for Novartis. Dr. Gorodeski has received research support and speaking and consultation compensation from Abbott.. Dr. Hernandez has received research grants and consulting for AstraZeneca, Amgen, Bayer, Merck and Novartis. Dr. Braunwald has received research support through his institution from AstraZeneca, Daiichi-Sankyo, Merck, and Novartis; and is a consultant for Amgen, Cardurion, MyoKardia, and NovoNordisk. All other authors have reported that they have no relationships relevant to the contents of this paper to disclose. The views expressed in this manuscript are those of the authors and do not necessarily represent the views of the National Heart, Lung, and Blood Institute, the National Institute of Arthritis and Infectious Diseases, the National Institutes of Health, or the U.S. Department of Health and Human Services.
Funding Information:
The LIFE trial was funded primarily by the National Heart, Lung, and Blood Institute (NHLBI) as part of the Heart Failure Clinical Research Network. Novartis supplied study drug and supplemental funding for coordinating center operations to support trial completion. The Duke Clinical Research Institute (Durham, North Carolina) was the coordinating center. Overall responsibility for the oversight and management of the trial lay with the LIFE Steering Committee, consisting of academic investigators and representatives from the NHLBI. The data and safety monitoring board included HF specialists and independent statistician and was responsible for active surveillance of safety data, including all adverse events. The LIFE trial protocol was approved by the Institutional Review Boards at all of the participating recruiting centers.
Funding Information:
Dr. Mann has served as a consultant for Novartis. Dr. Greene has received research support from Amgen, AztraZeneca, Bristol-Myers Squibb, Merck, and Novartis; and is a consultant for Amgen and Merck; is a member of the advisory boards of Amgen and Cytokinetics. Dr. Starling has served as a consultant for Novartis; and is on the steering committee for the PARAGLIDE trial. Dr. Ambrosy has received research support from Novartis; and has received personal fees for the PIONEER-HF trial. Dr. Shah is an employee of Inova Heart and Vascular Institute; has received grant support from Merck, Abbott, Bayer, Medtronic, and Pulse CV; and is a consultant for NuPulse, Ortho Clinical Diagnostics, and Procyrion. Dr. Mahr is a consultant for Abbott, Medtronic, and Abiomed. Dr. Lewis has been a consultant for and received research support from Cytokinetics and Applied Therapeutics; and received research support from Amgen and AstraZeneca. Dr. Mohammed is a member of the advisory board for Pfizer; and has received research support from Cardiocell, Abbott, Actelion, Corvia, and Medtronic. Dr. Gilotra is a consultant for scPharmaceuticals. Dr. DeVore has received research support through his institution from the American Heart Association, Amgen, AstraZeneca, Bayer, Intra-Cellular Therapies, American Regent, National Heart, Lung, Blood Institute, Novartis, and Patient-Centered Outcomes Research Institute; and is a consultant for Novartis. Dr. Desvigne-Nickens is an employee of the National Heart, Lung, and Blood Institute; and is a consultant for Novartis. Dr. Gorodeski has received research support and speaker and consultation compensation from Abbott. Dr. Hernandez has received research grants and consulting for AstraZeneca, Amgen, Bayer, Merck and Novartis. Dr. Braunwald has received research support through his institution from AstraZeneca, Daiichi-Sankyo, Merck, and Novartis; and is a consultant for Amgen, Cardurion, MyoKardia, and NovoNordisk. All other authors have reported that they have no relationships relevant to the contents of this paper to disclose. The views expressed in this manuscript are those of the authors and do not necessarily represent the views of the National Heart, Lung, and Blood Institute, the National Institute of Arthritis and Infectious Diseases, the National Institutes of Health, or the U.S. Department of Health and Human Services.