Safety and Efficacy of PrimeC in Amyotrophic Lateral Sclerosis: The PARADIGM Randomized Clinical Trial

Merit Cudkowicz; Vivian E. Drory; Adriano Chio; Christian Lunetta; Christen Shoesmith; Ruben P. A. van Eijk; Shiran Salomon-Zimri; Diana Shtossel; Nitai Kerem; Guy Shapira; Noam Shomron; Niva Russek-Blum; Ferenc Tracik; Jeffrey Rosenfeld; Jeremy Shefner

doi:10.1001/jamaneurol.2026.0230

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Safety and Efficacy of PrimeC in Amyotrophic Lateral Sclerosis: The PARADIGM Randomized Clinical Trial

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Safety and Efficacy of PrimeC in Amyotrophic Lateral Sclerosis: The PARADIGM Randomized Clinical Trial

Merit Cudkowicz, Vivian E. Drory, Adriano Chio, Christian Lunetta, Christen Shoesmith, Ruben P. A. van Eijk, Shiran Salomon-Zimri, Diana Shtossel, Nitai Kerem, Guy Shapira, …

JAMA neurology

03/16/2026

DOI: https://doi.org/10.1001/jamaneurol.2026.0230

PMID: 41837970

Abstract

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Online First

Original Investigation

This randomized clinical trial assesses the safety, tolerability, and potential efficacy of PrimeC in people living with ALS.

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Title: Safety and Efficacy of PrimeC in Amyotrophic Lateral Sclerosis
Creators: Merit Cudkowicz - Massachusetts General Hospital
Vivian E. Drory - Tel Aviv Sourasky Medical Center
Adriano Chio - Azienda Ospedaliera Citta' della Salute e della Scienza di Torino
Christian Lunetta - Istituti Clinici Scientifici Maugeri
Christen Shoesmith - London Health Sciences Centre
Ruben P. A. van Eijk - Utrecht University
Shiran Salomon-Zimri - Reichman University
Diana Shtossel - Reichman University
Nitai Kerem - Reichman University
Guy Shapira - Tel Aviv University
Noam Shomron - Tel Aviv University
Niva Russek-Blum - Reichman University
Ferenc Tracik - United Therapeutics (United States)
Jeffrey Rosenfeld - Loma Linda University
Jeremy Shefner - Barrow Neurological Institute
Publication Details: JAMA neurology
Grant note: NeuroSense Therapeutics
Identifiers: 991006262295902656
Academic Unit: Neurology
Language: English
Resource Type: Journal article