Abstract
Nontuberculous mycobacteria are widely distributed in the environment and have the potential to cause serious infections, particularly in immunocompromised patients. Allogeneic bone marrow transplant recipients have severely impaired cell-mediated immunity as a result of chemotherapy, radiation therapy, underlying disease, and graft-versus-host disease; thus, they are susceptible to infections by multiple organisms. Successful treatment of mycobacterial infections in bone marrow transplant patients can be difficult, requiring aggressive and rapid intervention. Novel antimicrobial combinations are necessary to overcome microbial resistance factors. We present a case of refractory Mycobacterium fortuitum osteomyelitis after allogeneic bone marrow transplantation that was treated successfully with tigecycline and moxifloxacin. © 2007 Lippincott Williams & Wilkins, Inc.