Surgical Considerations for Tumor Tissue Procurement to Obtain Tumor-Infiltrating Lymphocytes for Adoptive Cell Therapy

John E. Mullinax; Michael E. Egger; Martin McCarter; Bradley J. Monk; Eric M. Toloza; Susan Brousseau; Madan Jagasia; Amod Sarnaik

doi:10.1097/PPO.0000000000000608

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Surgical Considerations for Tumor Tissue Procurement to Obtain Tumor-Infiltrating Lymphocytes for Adoptive Cell Therapy

Journal article

Open access

Peer reviewed

Surgical Considerations for Tumor Tissue Procurement to Obtain Tumor-Infiltrating Lymphocytes for Adoptive Cell Therapy

John E. Mullinax, Michael E. Egger, Martin McCarter, Bradley J. Monk, Eric M. Toloza, Susan Brousseau, Madan Jagasia and Amod Sarnaik

The cancer journal (Sudbury, Mass.), Vol.28(4), pp.285-293

07/01/2022

DOI: https://doi.org/10.1097/PPO.0000000000000608

PMID: 35880938

Abstract

Best practices

Review

surgeon

surgical considerations

TIL cell therapy

tumor resection

tumor-infiltrating lymphocytes

Adoptive cell therapy with tumor-infiltrating lymphocytes (TILs), an investigational cellular therapy, has demonstrated antitumor efficacy in patients with advanced solid tumors, including melanoma. Tumor-infiltrating lymphocyte cell therapy involves surgical resection of a patient's tumor, ex vivo TIL expansion under conditions that overcome immunosuppressive responses elicited by the tumor and the tumor microenvironment, administration of a lymphodepleting regimen, and infusion of the final TIL cell therapy product back into the patient followed by interleukin 2 administration to support T-cell activity. The surgeon plays a central role in patient identification and tumor selection—steps that are critical for successful outcomes of TIL cell therapy. Commercialization of TIL cell therapy and its broader access to patients will require education and collaboration among surgeons, oncologists, and cellular therapists. This review highlights the unique role that surgeons will play in the implementation of TIL cell therapy and serves as a contemporary report of best practices for patient selection and tumor resection methods.

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Title: Surgical Considerations for Tumor Tissue Procurement to Obtain Tumor-Infiltrating Lymphocytes for Adoptive Cell Therapy
Creators: John E. Mullinax - From the Sarcoma Department, H. Lee Moffitt Cancer Center Departments of Surgery Oncologic Sciences, University of South Florida Health Morsani College of Medicine, Tampa, FL Department of Surgery, Division of Surgical Oncology, University of Louisville, Louisville, KY Department of Surgery, Division of Surgical Oncology, University of Colorado Anschutz Medical Campus, Aurora, CO HonorHealth Research Institute, University of Arizona College of Medicine, Creighton University School of Medicine, Phoenix, AZ Department of Thoracic Oncology, H. Lee Moffitt Cancer Center, Tampa, FL Iovance Biotherapeutics, San Carlos, CA Department of Cutaneous Oncology, H. Lee Moffitt Cancer Center, Tampa, FL
Michael E. Egger - University of Louisville
Martin McCarter - University of Colorado Anschutz Medical Campus
Bradley J. Monk - University of Arizona
Eric M. Toloza - From the Sarcoma Department, H. Lee Moffitt Cancer Center Departments of Surgery Oncologic Sciences, University of South Florida Health Morsani College of Medicine, Tampa, FL Department of Surgery, Division of Surgical Oncology, University of Louisville, Louisville, KY Department of Surgery, Division of Surgical Oncology, University of Colorado Anschutz Medical Campus, Aurora, CO HonorHealth Research Institute, University of Arizona College of Medicine, Creighton University School of Medicine, Phoenix, AZ Department of Thoracic Oncology, H. Lee Moffitt Cancer Center, Tampa, FL Iovance Biotherapeutics, San Carlos, CA Department of Cutaneous Oncology, H. Lee Moffitt Cancer Center, Tampa, FL
Susan Brousseau - Theravance Biopharma
Madan Jagasia - Theravance Biopharma
Amod Sarnaik - From the Sarcoma Department, H. Lee Moffitt Cancer Center Departments of Surgery Oncologic Sciences, University of South Florida Health Morsani College of Medicine, Tampa, FL Department of Surgery, Division of Surgical Oncology, University of Louisville, Louisville, KY Department of Surgery, Division of Surgical Oncology, University of Colorado Anschutz Medical Campus, Aurora, CO HonorHealth Research Institute, University of Arizona College of Medicine, Creighton University School of Medicine, Phoenix, AZ Department of Thoracic Oncology, H. Lee Moffitt Cancer Center, Tampa, FL Iovance Biotherapeutics, San Carlos, CA Department of Cutaneous Oncology, H. Lee Moffitt Cancer Center, Tampa, FL
Publication Details: The cancer journal (Sudbury, Mass.), Vol.28(4), pp.285-293
Publisher: Lippincott Williams & Wilkins
Identifiers: 991005968885402656
Academic Unit: Obstetrics & Gynecology
Language: English
Resource Type: Journal article