Synthesis of a disulfide cross-linked DNA triple helix

Jay T. Goodwin; Scott E. Osborne; Patrick C. Swanson; Gary D. Glick

doi:10.1016/S0040-4039(00)60718-9

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Synthesis of a disulfide cross-linked DNA triple helix

Journal article

Peer reviewed

Synthesis of a disulfide cross-linked DNA triple helix

Jay T. Goodwin, Scott E. Osborne, Patrick C. Swanson and Gary D. Glick

Tetrahedron Letters, Vol.35(26), pp.4527-4530

06/27/1994

DOI: https://doi.org/10.1016/S0040-4039(00)60718-9

Abstract

Biochemistry

Drug Discovery

Organic Chemistry

An intramolecular DNA triple helix incorporating a disulfide cross-link has been synthesized. Potassium permanganate footprinting and UV melting analysis demonstrate that the cross-link increases the conformational stability of this novel triplex at physiological pH and [Mg2+] relative to the unmodified sequence.

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Title: Synthesis of a disulfide cross-linked DNA triple helix
Creators: Jay T. Goodwin (Author) - University of Michigan, Ann Arbor
Scott E. Osborne (Author) - University of Michigan, Ann Arbor
Patrick C. Swanson (Author) - University of Michigan, Ann Arbor
Gary D. Glick (Author) - University of Michigan, Ann Arbor
Publication Details: Tetrahedron Letters, Vol.35(26), pp.4527-4530
Series: 35
Number of pages: 4
Identifiers: 991005928595302656
Academic Unit: Creighton University
Language: English
Resource Type: Journal article

Synthesis of a disulfide cross-linked DNA triple helix

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