Ten months of temporal variation in the clinical journey of hospitalised patients with COVID-19: An observational cohort

Matthew D. Hall; Joaquín Baruch; Gail Carson; Barbara Wanjiru Citarella; Andrew Dagens; Emmanuelle A. Dankwa; Christl A. Donnelly; Jake Dunning; Martina Escher; Christiana Kartsonaki; Laura Merson; Mark Pritchard; Jia Wei; Peter W. Horby; Amanda Rojek; Piero L. Olliaro; Sheryl Ann Abdukahil; Ryuzo Abe; Laurent Abel; Lara Absil; Subhash Acharya; Andrew Acker; Shingo Adachi; Elisabeth Adam; Diana Adrião; Saleh Al Ageel; Shakeel Ahmed; Kate Ainscough; Ali Ait Hssain; Younes Ait Tamlihat; Takako Akimoto; Ernita Akmal; Eman Al Qasim; Razi Alalqam; Tala Al-Dabbous; Senthilkumar Alegesan; Cynthia Alegre; Beatrice Alex; Kévin Alexandre; Abdulrahman Al-Fares; Huda Alfoudri; Imran Ali; Kazali Enagnon Alidjnou; Jeffrey Aliudin; Qabas Alkhafajee; Clotilde Allavena; Nathalie Allou; João Alves; Rita Alves; Maria Amaral; Heidi Ammerlaan; Phoebe Ampaw; Roberto Andini; Claire Andrejak; Andrea Angheben; François Angoulvant; Séverine Ansart; Massimo Antonelli; Carlos Alexandre Antunesde Brito; Ardiyan Apriyana; Yaseen Arabi; Irene Aragao; Francisco Arancibia; Carolline Araujo; Antonio Arcadipane; Patrick Archambault; Lukas Arenz; Jean-Benoît Arlet; Christel Arnold-Day; Lovkesh Arora; Rakesh Arora; Elise Artaud-Macari; Diptesh Aryal; Motohiro Asaki; Angel Asensio; Sheharyar Ashraf; Jean Baptiste Assie; Anika Atique; Amudara Lakshan Attanyake; Johann Auchabie; Hugues Aumaitre; Adrien Auvet; Laurène Azemar; Cecile Azoulay; Benjamin Bach; Delphine Bachelet; Claudine Badr; Nadia Baig; J. Kenneth Baillie; Erica Bak; Agamemnon Bakakos; Andriy Bal; Valeria Balan; Firouzé Bani-Sadr; Renata Barbalho; Wendy S. Barclay; Michaela Barnikel; Helena Barrasa; Audrey Barrelet; Cleide Barrigoto; Marie Bartoli; Cheryl Bartone; Romain Basmaci; Denise Battaglini; Jules Bauer; Diego Fernando Bautista Rincon; Abigail Beane; Alexandra Bedossa; Sylvie Behilill; Aleksandr Beljantsev; David Bellemare; Anna Beltrame; Marine Beluze; Nicolas Benech; Dehbia Benkerrou; Suzanne Bennett; Luís Bento; Jan-Erik Berdal; Delphine Bergeaud; Hazel Bergin; José Luis Bernal Sobrino; Giulia Bertoli; Lorenzo Bertolino; Simon Bessis; Adam Betz; Sybille Bevilcaqua; Karine Bezulier; Amar Bhatt; Krishna Bhavsar; Isabella Bianchi; Claudia Bianco; Moirangthem Bikram Singh; Felwa Bin Humaid; François Bissuel; Patrick Biston; Laurent Bitker; Pablo Blanco-Schweizer; Catherine Blier; Frank Bloos; Mathieu Blot; Filomena Boccia; Laetitia Bodenes; Alice Bogaarts; Debby Bogaert; Anne-Hélène Boivin; Pierre-Adrien Bolze; François Bompart; Diogo Borges; Raphaël Borie; Hans Martin Bosse; Elisabeth Botelho-Nevers; Lila Bouadma; Olivier Bouchaud; Sabelline Bouchez; Dounia Bouhmani; Damien Bouhour; Kévin Bouiller; Laurence Bouillet; Camile Bouisse; Anne-Sophie Boureau; John Bourke; Maude Bouscambert; Aurore Bousquet; Jason Bouziotis; Bianca Boxma; Marielle Boyer-Besseyre; Maria Boylan; Matthew Brack; Axelle Braconnier; Cynthia Braga; Timo Brandenburger; Filipa Brás Monteiro; Luca Brazzi; Dorothy Breen; Patrick Breen; Kathy Brickell; Alex Browne; Shaunagh Browne; Nicolas Brozzi; Nina Buchtele; Christian Buesaquillo; Marielle Buisson; Erlina Burhan; Ingrid G. Bustos; André Cabie; Susana Cabral; Eder Caceres; Cyril Cadoz; Kate Calligy; Jose Andres Calvache; João Cam; Valentine Campana; Paul Campbell; Cecilia Canepa; Mireia Cantero; Pauline Caraux-Paz; Sheila Cárcel; Chiara Simona Cardellino; Filipa Cardoso; Filipe Cardoso; Nelson Cardoso; Sofia Cardoso; Simone Carelli; Nicolas Carlier; Thierry Carmoi; Gayle Carney; Chloe Carpenter; Inês Carqueja; Marie-Christine Carret; François Martin Carrier; Ida Carroll; Ed Carton; Maire-Laure Casanova; Mariana Cascão; Siobhan Casey; José Casimiro; Bailey Cassandra; Silvia Castañeda; Nidyanara Castanheira; Guylaine Castor-Alexandre; Henry Castrillón; Ivo Castro; Ana Catarino; François-Xavier Catherine; Paolo Cattaneo; Roberta Cavalin; Giulio Giovanni Cavalli; Alexandros Cavayas; Adrian Ceccato; Minerva Cervantes-Gonzalez; Anissa Chair; Catherine Chakveatze; Adrienne Chan; Meera Chand; Christelle Chantalat Auger; Jean-Marc Chapplain; Julie Chas; Jonathan Samuel Chávez Iñiguez; Anjellica Chen; Yih-Sharng Chen; Matthew Pellan Cheng; Antoine Cheret; Thibault Chiarabini; Julian Chica; Catherine Chirouze; Davide Chiumello; Hwa Jin Cho; Sung-Min Cho; Bernard Cholley; Marie-Charlotte Chopin; Josepedro Cidade; Anna Ciullo; Jennifer Clarke; Sara Clohisey; Necsoi Coca; Cassidy Codan; Caitriona Cody; Alexandra Coelho; Megan Coles; Gwenhaël Colin; Michael Collins; Sebastiano Maria Colombo; Pamela Combs; Jennifer Connolly; Marie Connor; Anne Conrad; Sofía Contreras; Elaine Conway; Graham S. Cooke; Mary Copland; Hugues Cordel; Amanda Corley; Sarah Cormican; Sabine Cornelis; Arianne Joy Corpuz; Grégory Corvaisier; Camille Couffignal; Sandrine Couffin-Cadiergues; Roxane Courtois; Stéphanie Cousse; Sabine Croonen; Gloria Crowl; Jonathan Crump; Claudina Cruz; Juan Luis Cruz Berm; Jaime Cruz Rojo; Marc Csete; Alberto Cucino; Ailbhe Cullen; Caroline Cullen; Matthew Cummings; Ger Curley; Elodie Curlier; Colleen Curran; Paula Custodio; Anada Silva Filipe; Charlene Da Silveira; Al-Awwab Dabaliz; Darren Dahly; Heidi Dalton; Jo Dalton; Seamus Daly; D

doi:10.7554/eLife.70970

Journal article

Ten months of temporal variation in the clinical journey of hospitalised patients with COVID-19: An observational cohort

Matthew D. Hall, Joaquín Baruch, Gail Carson, Barbara Wanjiru Citarella, Andrew Dagens, Emmanuelle A. Dankwa, Christl A. Donnelly, Jake Dunning, Martina Escher, Christiana Kartsonaki, …

eLife

2021

DOI: https://doi.org/10.7554/eLife.70970

Abstract

abdominal pain

adolescent

adult

aged

ageusia

anosmia

Article

bleeding

case fatality rate

child

chronic kidney failure

cohort analysis

confusion

coronavirus disease 2019

coughing

dementia

dyspnea

epidemic

fatigue

female

fever

hospital bed utilization

hospital infection

hospital patient

human

hypertension

intensive care unit

lymphadenopathy

major clinical study

male

malnutrition

middle aged

myalgia

observational study

otalgia

prevalence

rash

ulcer

vomiting

wheezing

Background: There is potentially considerable variation in the nature and duration of the care provided to hospitalised patients during an infectious disease epidemic or pandemic. Improvements in care and clinician confidence may shorten the time spent as an inpatient, or the need for admission to an intensive care unit (ICU) or high density unit (HDU). On the other hand, limited resources at times of high demand may lead to rationing. Nevertheless, these variables may be used as static proxies for disease severity, as outcome measures for trials, and to inform planning and logistics. Methods: We investigate these time trends in an extremely large international cohort of 142,540 patients hospitalised with COVID-19. Investigated are: Time from symptom onset to hospital admission, probability of ICU/HDU admission, time from hospital admission to ICU/HDU admission, hospital case fatality ratio (hCFR) and total length of hospital stay. Results: Time from onset to admission showed a rapid decline during the first months of the pandemic followed by peaks during August/September and December 2020. ICU/HDU admission was more frequent from June to August. The hCFR was lowest from June to August. Raw numbers for overall hospital stay showed little variation, but there is clear decline in time to discharge for ICU/HDU survivors. Conclusions: Our results establish that variables of these kinds have limitations when used as outcome measures in a rapidly-evolving situation. Funding: This work was supported by the UK Foreign, Commonwealth and Development Office and Wellcome [215091/Z/18/Z] and the Bill and Melinda Gates Foundation [OPP1209135]. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. © 2021, eLife Sciences Publications Ltd. All rights reserved.

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Title: Ten months of temporal variation in the clinical journey of hospitalised patients with COVID-19: An observational cohort
Creators: Matthew D. Hall - University of Oxford
Joaquín Baruch - University of Oxford
Gail Carson - University of Oxford
Barbara Wanjiru Citarella - University of Oxford
Andrew Dagens - University of Oxford
Emmanuelle A. Dankwa - University of Oxford
Christl A. Donnelly - Imperial College London
Jake Dunning - University of Oxford
Martina Escher - University of Oxford
Christiana Kartsonaki - University of Oxford
Laura Merson - University of Oxford
Mark Pritchard - University of Oxford
Jia Wei - University of Oxford
Peter W. Horby - University of Oxford
Amanda Rojek - Royal Melbourne Hospital
Piero L. Olliaro - University of Oxford
Sheryl Ann Abdukahil
Ryuzo Abe
Laurent Abel
Lara Absil
Subhash Acharya
Andrew Acker
Shingo Adachi
Elisabeth Adam
Diana Adrião
Saleh Al Ageel
Shakeel Ahmed
Kate Ainscough
Ali Ait Hssain
Younes Ait Tamlihat
Takako Akimoto
Ernita Akmal
Eman Al Qasim
Razi Alalqam
Tala Al-Dabbous
Senthilkumar Alegesan
Cynthia Alegre
Beatrice Alex
Kévin Alexandre
Abdulrahman Al-Fares
Huda Alfoudri
Imran Ali
Kazali Enagnon Alidjnou
Jeffrey Aliudin
Qabas Alkhafajee
Clotilde Allavena
Nathalie Allou
João Alves
Rita Alves
Maria Amaral
Heidi Ammerlaan
Phoebe Ampaw
Roberto Andini
Claire Andrejak
Andrea Angheben
François Angoulvant
Séverine Ansart
Massimo Antonelli
Carlos Alexandre Antunesde Brito
Ardiyan Apriyana
Yaseen Arabi
Irene Aragao
Francisco Arancibia
Carolline Araujo
Antonio Arcadipane
Patrick Archambault
Lukas Arenz
Jean-Benoît Arlet
Christel Arnold-Day
Lovkesh Arora
Rakesh Arora
Elise Artaud-Macari
Diptesh Aryal
Motohiro Asaki
Angel Asensio
Sheharyar Ashraf
Jean Baptiste Assie
Anika Atique
Amudara Lakshan Attanyake
Johann Auchabie
Hugues Aumaitre
Adrien Auvet
Laurène Azemar
Cecile Azoulay
Benjamin Bach
Delphine Bachelet
Claudine Badr
Nadia Baig
J. Kenneth Baillie
Erica Bak
Agamemnon Bakakos
Andriy Bal
Valeria Balan
Firouzé Bani-Sadr
Renata Barbalho
Wendy S. Barclay
Michaela Barnikel
Helena Barrasa
Audrey Barrelet
Cleide Barrigoto
Marie Bartoli
Cheryl Bartone
Romain Basmaci
Denise Battaglini
Jules Bauer
Diego Fernando Bautista Rincon
Abigail Beane
Alexandra Bedossa
Sylvie Behilill
Aleksandr Beljantsev
David Bellemare
Anna Beltrame
Marine Beluze
Nicolas Benech
Dehbia Benkerrou
Suzanne Bennett
Luís Bento
Jan-Erik Berdal
Delphine Bergeaud
Hazel Bergin
José Luis Bernal Sobrino
Giulia Bertoli
Lorenzo Bertolino
Simon Bessis
Adam Betz
Sybille Bevilcaqua
Karine Bezulier
Amar Bhatt
Krishna Bhavsar
Isabella Bianchi
Claudia Bianco
Moirangthem Bikram Singh
Felwa Bin Humaid
François Bissuel
Patrick Biston
Laurent Bitker
Pablo Blanco-Schweizer
Catherine Blier
Frank Bloos
Mathieu Blot
Filomena Boccia
Laetitia Bodenes
Alice Bogaarts
Debby Bogaert
Anne-Hélène Boivin
Pierre-Adrien Bolze
François Bompart
Diogo Borges
Raphaël Borie
Hans Martin Bosse
Elisabeth Botelho-Nevers
Lila Bouadma
Olivier Bouchaud
Sabelline Bouchez
Dounia Bouhmani
Damien Bouhour
Kévin Bouiller
Laurence Bouillet
Camile Bouisse
Anne-Sophie Boureau
John Bourke
Maude Bouscambert
Aurore Bousquet
Jason Bouziotis
Bianca Boxma
Marielle Boyer-Besseyre
Maria Boylan
Matthew Brack
Axelle Braconnier
Cynthia Braga
Timo Brandenburger
Filipa Brás Monteiro
Luca Brazzi
Dorothy Breen
Patrick Breen
Kathy Brickell
Alex Browne
Shaunagh Browne
Nicolas Brozzi
Nina Buchtele
Christian Buesaquillo
Marielle Buisson
Erlina Burhan
Ingrid G. Bustos
André Cabie
Susana Cabral
Eder Caceres
Cyril Cadoz
Kate Calligy
Jose Andres Calvache
João Cam
Valentine Campana
Paul Campbell
Cecilia Canepa
Mireia Cantero
Pauline Caraux-Paz
Sheila Cárcel
Chiara Simona Cardellino
Filipa Cardoso
Filipe Cardoso
Nelson Cardoso
Sofia Cardoso
Simone Carelli
Nicolas Carlier
Thierry Carmoi
Gayle Carney
Chloe Carpenter
Inês Carqueja
Marie-Christine Carret
François Martin Carrier
Ida Carroll
Ed Carton
Maire-Laure Casanova
Mariana Cascão
Siobhan Casey
José Casimiro
Bailey Cassandra
Silvia Castañeda
Nidyanara Castanheira
Guylaine Castor-Alexandre
Henry Castrillón
Ivo Castro
Ana Catarino
François-Xavier Catherine
Paolo Cattaneo
Roberta Cavalin
Giulio Giovanni Cavalli
Alexandros Cavayas
Adrian Ceccato
Minerva Cervantes-Gonzalez
Anissa Chair
Catherine Chakveatze
Adrienne Chan
Meera Chand
Christelle Chantalat Auger
Jean-Marc Chapplain
Julie Chas
Jonathan Samuel Chávez Iñiguez
Anjellica Chen
Yih-Sharng Chen
Matthew Pellan Cheng
Antoine Cheret
Thibault Chiarabini
Julian Chica
Catherine Chirouze
Davide Chiumello
Hwa Jin Cho
Sung-Min Cho
Bernard Cholley
Marie-Charlotte Chopin
Josepedro Cidade
Anna Ciullo
Jennifer Clarke
Sara Clohisey
Necsoi Coca
Cassidy Codan
Caitriona Cody
Alexandra Coelho
Megan Coles
Gwenhaël Colin
Michael Collins
Sebastiano Maria Colombo
Pamela Combs
Jennifer Connolly
Marie Connor
Anne Conrad
Sofía Contreras
Elaine Conway
Graham S. Cooke
Mary Copland
Hugues Cordel
Amanda Corley
Sarah Cormican
Sabine Cornelis
Arianne Joy Corpuz
Grégory Corvaisier
Camille Couffignal
Sandrine Couffin-Cadiergues
Roxane Courtois
Stéphanie Cousse
Sabine Croonen
Gloria Crowl
Jonathan Crump
Claudina Cruz
Juan Luis Cruz Berm
Jaime Cruz Rojo
Marc Csete
Alberto Cucino
Ailbhe Cullen
Caroline Cullen
Matthew Cummings
Ger Curley
Elodie Curlier
Colleen Curran
Paula Custodio
Anada Silva Filipe
Charlene Da Silveira
Al-Awwab Dabaliz
Darren Dahly
Heidi Dalton
Jo Dalton
Seamus Daly
D
Publication Details: eLife
Publisher: eLife Sciences Publications Ltd
Identifiers: 991006162962402656
Language: English
Resource Type: Journal article