Abstract
The purpose of this manuscript is to examine the known and theoretical mechanical effects of therapeutic manual techniques on the connective tissue (CT) of joints and fasciae. Typical CT structures that could be influenced by manual techniques will be discussed. The behavior of CT under loading and the influence of immobilization on CT will be examined. The forces developed during manual techniques will be described, and their potential effects on the physical properties of CT will be discussed. Research priorities regarding the effects of manual therapy on CT will be outlined.