Thirty new loci for age at menarche identified by a meta-analysis of genome-wide association studies

Cathy E. Elks; John R.B. Perry; Patrick Sulem; Daniel I. Chasman; Nora Franceschini; Chunyan He; Kathryn L. Lunetta; Jenny A. Visser; Enda M. Byrne; Diana L. Cousminer; Daniel F. Gudbjartsson; Tõnu Esko; Bjarke Feenstra; Jouke Jan Hottenga; Daniel L. Koller; Zoltán Kutalik; Peng Lin; Massimo Mangino; Mara Marongiu; Patrick F. McArdle; Albert V. Smith; Lisette Stolk; Sophie H. Van Wingerden; Jing Hua Zhao; Eva Albrecht; Tanguy Corre; Erik Ingelsson; Caroline Hayward; Patrik K.E. Magnusson; Erin N. Smith; Shelia Ulivi; Nicole M. Warrington; Lina Zgaga; Helen Alavere; Najaf Amin; Thor Aspelund; Stefania Bandinelli; Inês Barroso; Gerald S. Berenson; Sven Bergmann; Hannah Blackburn; Eric Boerwinkle; Julie E. Buring; Fabio Busonero; Harry Campbell; Stephen J. Chanock; Wei Chen; Marilyn C. Cornelis; David Couper; Andrea D. Coviello; Pio D'Adamo; Ulf De Faire; Eco J.C. De Geus; Panos Deloukas; Angela Döring; George Davey Smith; Douglas F. Easton; Gudny Eiriksdottir; Valur Emilsson; Johan Eriksson; Luigi Ferrucci; Aaron R. Folsom; Tatiana Foroud; Melissa Garcia; Paolo Gasparini; Frank Geller; Christian Gieger; Vilmundur Gudnason; Per Hall; Susan E. Hankinson; Liana Ferreli; Andrew C. Heath; Dena G. Hernandez; Albert Hofman; Frank B. Hu; Thomas Illig; Marjo Riitta Järvelin; Andrew D. Johnson; David Karasik; Kay Tee Khaw; Douglas P. Kiel; Tuomas O. Kilpelänen; Ivana Kolcic; Peter Kraft; Lenore J. Launer; Joop S.E. Laven; Shengxu Li; Jianjun Liu; Daniel Levy; Nicholas G. Martin; Wendy L. McArdle; Mads Melbye; Vincent Mooser; Jeffrey C. Murray; Sarah S. Murray; Michael A. Nalls; Pau Navarro; Mari Nelis; Andrew R. Ness; Kate Northstone; Ben A. Oostra; Munro Peacock; Lyle J. Palmer; Aarno Palotie; Guillaume Paré; Alex N. Parker; Nancy L. Pedersen; Leena Peltonen; Craig E. Pennell; Paul Pharoah; Ozren Polasek; Andrew S. Plump; Anneli Pouta; Eleonora Porcu; Thorunn Rafnar; John P. Rice; Susan M. Ring; Fernando Rivadeneira; Igor Rudan; Cinzia Sala; Veikko Salomaa; Serena Sanna; David Schlessinger; Nicholas J. Schork; Angelo Scuteri; Ayellet V. Segrè; Alan R. Shuldiner; Nicole Soranzo; Ulla Sovio; Sathanur R. Srinivasan; David P. Strachan; Mar Liis Tammesoo; Emmi Tikkanen; Daniela Toniolo; Kim Tsui; Laufey Tryggvadottir; Jonathon Tyrer; Manuela Uda; Rob M. Van Dam; Joyce B.J. Van Meurs; Peter Vollenweider; Gerard Waeber; Nicholas J. Wareham; Dawn M. Waterworth; Michael N. Weedon; H. Erich Wichmann; Gonneke Willemsen; James F. Wilson; Alan F. Wright; Lauren Young; Guangju Zhai; Wei Vivian Zhuang; Laura J. Bierut; Dorret I. Boomsma; Heather A. Boyd; Laura Crisponi; Ellen W. Demerath; Cornelia M. Van Duijn; Michael J. Econs; Tamara B. Harris; David J. Hunter; Ruth J.F. Loos; Andres Metspalu; Grant W. Montgomery; Paul M. Ridker; Tim D. Spector; Elizabeth A. Streeten; Kari Stefansson; Unnur Thorsteinsdottir; André G. Uitterlinden; Elisabeth Widen; Joanne M. Murabito; Ken K. Ong; Anna Murray

doi:10.1038/ng.714

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Thirty new loci for age at menarche identified by a meta-analysis of genome-wide association studies

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Thirty new loci for age at menarche identified by a meta-analysis of genome-wide association studies

Cathy E. Elks, John R.B. Perry, Patrick Sulem, Daniel I. Chasman, Nora Franceschini, Chunyan He, Kathryn L. Lunetta, Jenny A. Visser, Enda M. Byrne, Diana L. Cousminer, …

Nature genetics, Vol.42(12), pp.1077-1085

12/01/2010

DOI: https://doi.org/10.1038/ng.714

Abstract

Genetics

To identify loci for age at menarche, we performed a meta-analysis of 32 genome-wide association studies in 87,802 women of European descent, with replication in up to 14,731 women. In addition to the known loci at LIN28B (P = 5.4 × 10 -60) and 9q31.2 (P = 2.2 × 10 -33), we identified 30 new menarche loci (all P <5 × 10 -8) and found suggestive evidence for a further 10 loci (P <1.9 × 10 -6). The new loci included four previously associated with body mass index (in or near FTO, SEC16B, TRA2B and TMEM18), three in or near other genes implicated in energy homeostasis (BSX, CRTC1 and MCHR2) and three in or near genes implicated in hormonal regulation (INHBA, PCSK2 and RXRG). Ingenuity and gene-set enrichment pathway analyses identified coenzyme A and fatty acid biosynthesis as biological processes related to menarche timing.

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Title: Thirty new loci for age at menarche identified by a meta-analysis of genome-wide association studies
Creators: Cathy E. Elks (Author) - Cambridge University Hospitals NHS Foundation Trust
John R.B. Perry (Author) - University of Exeter
Patrick Sulem (Author) - deCODE Genetics
Daniel I. Chasman (Author) - Harvard University
Nora Franceschini (Author) - University of North Carolina at Chapel Hill
Chunyan He (Author) - Indiana University Bloomington
Kathryn L. Lunetta (Author) - National Heart, Lung, and Blood Institute's The Framingham Heart Study;Boston University
Jenny A. Visser (Author) - Erasmus University Rotterdam
Enda M. Byrne (Author) - Queensland Institute of Medical Research;University of Queensland
Diana L. Cousminer (Author) - University of Helsinki
Daniel F. Gudbjartsson (Author) - deCODE Genetics
Tõnu Esko (Author) - Estonian Biocentre;University of Tartu
Bjarke Feenstra (Author) - Statens Serum Institut
Jouke Jan Hottenga (Author) - Vrije Universiteit Amsterdam
Daniel L. Koller (Author) - Indiana University Bloomington
Zoltán Kutalik (Author) - University of Lausanne;Swiss Institute of Bioinformatics
Peng Lin (Author) - Washington University St. Louis
Massimo Mangino (Author) - King's College London
Mara Marongiu (Author) - National Research Council of Italy
Patrick F. McArdle (Author) - University of Maryland, Baltimore
Albert V. Smith (Author) - Icelandic Heart Association;University of Iceland
Lisette Stolk (Author) - Erasmus University Rotterdam;Netherlands Consortium of Healthy Aging
Sophie H. Van Wingerden (Author) - Erasmus University Rotterdam
Jing Hua Zhao (Author) - Cambridge University Hospitals NHS Foundation Trust
Eva Albrecht (Author) - Helmholtz Zentrum München - German Research Center for Environmental Health
Tanguy Corre (Author) - IRCCS San Raffaele Scientific Institute
Erik Ingelsson (Author) - Karolinska Institutet
Caroline Hayward (Author) - Western General Hospital
Patrik K.E. Magnusson (Author) - Karolinska Institutet
Erin N. Smith (Author) - Scripps Genomic Medicine;Scripps Research Translational Institute;Scripps Research Institute
Shelia Ulivi (Author) - University of Trieste
Nicole M. Warrington (Author) - University of Western Australia
Lina Zgaga (Author) - University of Edinburgh
Helen Alavere (Author) - Estonian Biocentre
Najaf Amin (Author) - Erasmus University Rotterdam
Thor Aspelund (Author) - Icelandic Heart Association;University of Iceland
Stefania Bandinelli (Author) - Geriatric Unit
Inês Barroso (Author) - Wellcome Sanger Institute
Gerald S. Berenson (Author) - Tulane University
Sven Bergmann (Author) - University of Lausanne;Swiss Institute of Bioinformatics
Hannah Blackburn (Author) - Wellcome Sanger Institute
Eric Boerwinkle (Author) - University of Texas Health Science Center at Houston
Julie E. Buring (Author) - Harvard University
Fabio Busonero (Author) - National Research Council of Italy
Harry Campbell (Author) - University of Edinburgh
Stephen J. Chanock (Author) - National Institutes of Health
Wei Chen (Author) - Tulane University
Marilyn C. Cornelis (Author) - Harvard University
David Couper (Author) - University of North Carolina at Chapel Hill
Andrea D. Coviello (Author) - Boston University
Pio D'Adamo (Author) - University of Trieste
Ulf De Faire (Author) - Karolinska Institutet
Eco J.C. De Geus (Author) - Vrije Universiteit Amsterdam
Panos Deloukas (Author) - Wellcome Sanger Institute
Angela Döring (Author) - Helmholtz Zentrum München - German Research Center for Environmental Health
George Davey Smith (Author) - University of Bristol
Douglas F. Easton (Author) - University of Cambridge
Gudny Eiriksdottir (Author) - Icelandic Heart Association
Valur Emilsson (Author) - Merck
Johan Eriksson (Author) - National Institute for Health and Welfare;University of Helsinki;Folkhalsan
Luigi Ferrucci (Author) - National Institutes of Health
Aaron R. Folsom (Author) - University of Minnesota Twin Cities
Tatiana Foroud (Author) - Indiana University Bloomington
Melissa Garcia (Author) - National Institutes of Health
Paolo Gasparini (Author) - University of Trieste
Frank Geller (Author) - Statens Serum Institut
Christian Gieger (Author) - Helmholtz Zentrum München - German Research Center for Environmental Health
Vilmundur Gudnason (Author) - Icelandic Heart Association;University of Iceland
Per Hall (Author) - Karolinska Institutet
Susan E. Hankinson (Author) - Harvard University
Liana Ferreli (Author) - National Research Council of Italy
Andrew C. Heath (Author) - Washington University St. Louis
Dena G. Hernandez (Author) - National Institute of Aging
Albert Hofman (Author) - Netherlands Consortium of Healthy Aging;Erasmus University Rotterdam
Frank B. Hu (Author) - Harvard University
Thomas Illig (Author) - Helmholtz Zentrum München - German Research Center for Environmental Health
Marjo Riitta Järvelin (Author) - Imperial College London
Andrew D. Johnson (Author) - National Heart, Lung, and Blood Institute's The Framingham Heart Study;National Institutes of Health
David Karasik (Author) - Harvard University
Kay Tee Khaw (Author) - University of Cambridge
Douglas P. Kiel (Author) - Harvard University
Tuomas O. Kilpelänen (Author) - Cambridge University Hospitals NHS Foundation Trust
Ivana Kolcic (Author) - University of Zagreb
Peter Kraft (Author) - Harvard University
Lenore J. Launer (Author) - National Institutes of Health
Joop S.E. Laven (Author) - Erasmus University Rotterdam
Shengxu Li (Author) - Cambridge University Hospitals NHS Foundation Trust
Jianjun Liu (Author) - Agency for Science, Technology and Research, Singapore
Daniel Levy (Author) - National Heart, Lung, and Blood Institute's The Framingham Heart Study;National Institutes of Health;Boston University
Nicholas G. Martin (Author) - Queensland Institute of Medical Research
Wendy L. McArdle (Author) - University of Bristol
Mads Melbye (Author) - Statens Serum Institut
Vincent Mooser (Author) - GlaxoSmithKline
Jeffrey C. Murray (Author) - University of Iowa
Sarah S. Murray (Author) - Scripps Genomic Medicine;Scripps Research Translational Institute;Scripps Research Institute
Michael A. Nalls (Author) - National Institutes of Health
Pau Navarro (Author) - Western General Hospital
Mari Nelis (Author) - Estonian Biocentre;University of Tartu
Andrew R. Ness (Author) - University of Bristol
Kate Northstone (Author) - University of Bristol
Ben A. Oostra (Author) - Erasmus University Rotterdam
Munro Peacock (Author) - Indiana University Bloomington
Lyle J. Palmer (Author) - University of Western Australia
Aarno Palotie (Author) - University of Helsinki;Wellcome Sanger Institute;Massachusetts Institute of Technology
Guillaume Paré (Author) - Harvard University;McMaster University
Alex N. Parker (Author) - Amgen Incorporated
Nancy L. Pedersen (Author) - Karolinska Institutet
Leena Peltonen (Author) - University of Helsinki;Wellcome Sanger Institute;National Institute for Health and Welfare;Massachusetts Institute of Technology;University of Cambridge
Craig E. Pennell (Author) - University of Western Australia
Paul Pharoah (Author) - University of Cambridge
Ozren Polasek (Author) - University of Zagreb;Gen-Info Ltd
Andrew S. Plump (Author) - Merck
Anneli Pouta (Author) - National Institute for Health and Welfare
Eleonora Porcu (Author) - National Research Council of Italy
Thorunn Rafnar (Author) - deCODE Genetics
John P. Rice (Author) - Washington University St. Louis
Susan M. Ring (Author) - University of Bristol
Fernando Rivadeneira (Author) - Erasmus University Rotterdam;Netherlands Consortium of Healthy Aging
Igor Rudan (Author) - University of Edinburgh;University of Split
Cinzia Sala (Author) - IRCCS San Raffaele Scientific Institute
Veikko Salomaa (Author) - National Institute for Health and Welfare
Serena Sanna (Author) - National Research Council of Italy
David Schlessinger (Author) - National Institutes of Health
Nicholas J. Schork (Author) - Scripps Genomic Medicine;Scripps Research Translational Institute;Scripps Research Institute
Angelo Scuteri (Author) - National Research Council of Italy;Istituto Nazionale di Riposo e Cura per Anziani - Ancona
Ayellet V. Segrè (Author) - Massachusetts Institute of Technology;Harvard University
Alan R. Shuldiner (Author) - University of Maryland, Baltimore;Department of Veterans Affairs
Nicole Soranzo (Author) - King's College London;Wellcome Sanger Institute
Ulla Sovio (Author) - Imperial College London
Sathanur R. Srinivasan (Author) - Tulane University
David P. Strachan (Author) - St George's Hospital London
Mar Liis Tammesoo (Author) - Estonian Biocentre
Emmi Tikkanen (Author) - University of Helsinki;National Institute for Health and Welfare
Daniela Toniolo (Author) - IRCCS San Raffaele Scientific Institute
Kim Tsui (Author) - Amgen Incorporated
Laufey Tryggvadottir (Author) - Icelandic Cancer Registry
Jonathon Tyrer (Author) - University of Cambridge
Manuela Uda (Author) - National Research Council of Italy
Rob M. Van Dam (Author) - Harvard University;National University of Singapore
Joyce B.J. Van Meurs (Author) - Erasmus University Rotterdam;Netherlands Consortium of Healthy Aging
Peter Vollenweider (Author) - University of Lausanne
Gerard Waeber (Author) - University of Lausanne
Nicholas J. Wareham (Author) - Cambridge University Hospitals NHS Foundation Trust
Dawn M. Waterworth (Author) - GlaxoSmithKline
Michael N. Weedon (Author) - University of Exeter
H. Erich Wichmann (Author) - Helmholtz Zentrum München - German Research Center for Environmental Health;Ludwig Maximilian University of Munich
Gonneke Willemsen (Author) - Vrije Universiteit Amsterdam
James F. Wilson (Author) - University of Edinburgh
Alan F. Wright (Author) - Western General Hospital
Lauren Young (Author) - Amgen Incorporated
Guangju Zhai (Author) - King's College London
Wei Vivian Zhuang (Author) - Public Health
Laura J. Bierut (Author) - Washington University St. Louis
Dorret I. Boomsma (Author) - Vrije Universiteit Amsterdam
Heather A. Boyd (Author) - Statens Serum Institut
Laura Crisponi (Author) - National Research Council of Italy
Ellen W. Demerath (Author) - University of Minnesota Twin Cities
Cornelia M. Van Duijn (Author) - Netherlands Consortium of Healthy Aging;Erasmus University Rotterdam
Michael J. Econs (Author) - Indiana University Bloomington
Tamara B. Harris (Author) - National Institutes of Health
David J. Hunter (Author) - Harvard University;National Institutes of Health
Ruth J.F. Loos (Author) - Cambridge University Hospitals NHS Foundation Trust
Andres Metspalu (Author) - Estonian Biocentre;University of Tartu
Grant W. Montgomery (Author) - Queensland Institute of Medical Research
Paul M. Ridker (Author) - Harvard University
Tim D. Spector (Author) - King's College London
Elizabeth A. Streeten (Author) - University of Maryland, Baltimore
Kari Stefansson (Author) - deCODE Genetics;University of Iceland
Unnur Thorsteinsdottir (Author) - deCODE Genetics;University of Iceland
André G. Uitterlinden (Author) - Erasmus University Rotterdam;Netherlands Consortium of Healthy Aging
Elisabeth Widen (Author) - University of Helsinki
Joanne M. Murabito (Author) - Harvard University;Boston University
Ken K. Ong (Author) - Cambridge University Hospitals NHS Foundation Trust;University of Cambridge
Anna Murray (Author) - University of Exeter
Publication Details: Nature genetics, Vol.42(12), pp.1077-1085
Series: 42
Number of pages: 9
Identifiers: 991005929953002656
Academic Unit: Master Public Health
Language: English
Resource Type: Journal article

Thirty new loci for age at menarche identified by a meta-analysis of genome-wide association studies

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