Abstract
e13794 Background: Follicular thyroid cancer (FTC) is a prevalent endocrine malignancy, typically managed with surgical resection. Few studies have investigated the optimal time of surgery for FTC at a national registry level. The aim of this study is to examine the impact of delaying surgical intervention on survival in FTC. Methods: Patients from the Surveillance, Epidemiology, and End Results (SEER) database who were diagnosed with FTC between 2000-2020 were selected. Additional variables were collected including age, sex, race, stage, surgical status, radiation status, time to treatment, household income, and population size. Kaplan-Meier, and one- and five-year logistic regression analyses were performed. Results: A total of 10,478 patients were included of which 95.5% underwent surgical management. There was a 98.3% and 96.4% survival rate at one- and five-years, respectively. On Kaplan-Meier, those who underwent surgery survived longer (p<0.001). Additionally, patients treated within one month of diagnosis survived significantly better than those treated later (p<0.001). On one-year logistic regression, higher staging was associated with worse survival while those who received surgery, radiation, and lived in counties with a median household income >$75,000 had better survival (p’s<0.05). On five-year logistic regression, patients older than 50 years old and higher staging were associated with worse survival while those who received surgery had better survival (p’s<0.001). No differences were observed for time to treatment at one or five years. Conclusions: Our results show that surgical management is associated with improved survival in patients with FTC. On univariate analysis, a duration of one month or less between diagnosis and treatment was associated with improved survival. However, on multivariate analysis, only surgical management, radiation, and median household income >$75,000 were associated with improved survival.