Topical delivery of 5-fluorouracil and 6-mercaptopurine by their alkylcarbonyloxymethyl prodrugs from water: Vehicle effects on design of prodrugs

Journal article

Peer reviewed

Kenneth B. Sloan, Scott Wasdo, Udo Ezike-Mkparu, Thomas Murray, Donna Nickels, Surjit Singh, Thea Shanks, John Tovar, Karen Ulmer and Robert Waranis

Pharmaceutical research, Vol.20(4), pp.639-645

04/01/2003

PMID: 12739773

Abstract

Diffusion cell experiments

Flux

Lipid solubility

Prodrugs

Transformed Potts-Guy equation

Water solubility

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Title: Topical delivery of 5-fluorouracil and 6-mercaptopurine by their alkylcarbonyloxymethyl prodrugs from water: Vehicle effects on design of prodrugs
Creators: Kenneth B. Sloan - Florida College
Scott Wasdo - University of Florida
Udo Ezike-Mkparu - University of Florida
Thomas Murray - University of Florida
Donna Nickels - University of Florida
Surjit Singh - University of Florida
Thea Shanks - University of Florida
John Tovar - University of Florida
Karen Ulmer - University of Florida
Robert Waranis - University of Florida
Publication Details: Pharmaceutical research, Vol.20(4), pp.639-645
Number of pages: 7
Grant note: National Institutes of Health (http://data.elsevier.com/vocabulary/SciValFunders/100000002) R15CA067230 / National Cancer Institute (http://data.elsevier.com/vocabulary/SciValFunders/100000054) National Cancer Institute (http://data.elsevier.com/vocabulary/SciValFunders/100000054)
Identifiers: 991006262567702656
Academic Unit: Pharmacology and Neuroscience
Language: English
Resource Type: Journal article