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Unintended Consequences of Pretransplant Vancomycin-Resistant Enterococcus Screening on Antimicrobial Stewardship among Allogeneic Hematopoietic Cell Transplant Recipients
Journal article

Unintended Consequences of Pretransplant Vancomycin-Resistant Enterococcus Screening on Antimicrobial Stewardship among Allogeneic Hematopoietic Cell Transplant Recipients

Erica J. Stohs, Trenton MacAllister, Steven A. Pergam, Elizabeth M. Krantz, Rupali Jain, Ania Sweet and Catherine Liu
Infection Control and Hospital Epidemiology, Vol.39(6)
2018
DOI: https://doi.org/10.1017/ice.2018.43

Abstract

Adolescent Adult Aged Anti-Bacterial Agents Antimicrobial Stewardship Bacteremia Cancer Care Facilities Female Gram-Positive Bacterial Infections Hematopoietic Stem Cell Transplantation Humans Male Middle Aged Regression Analysis Retrospective Studies Transplantation, Homologous Vancomycin-Resistant Enterococci Washington Young Adult antiinfective agent dalfopristin plus quinupristin daptomycin linezolid antiinfective agent adult allogeneic hematopoietic stem cell transplantation antibiotic sensitivity antimicrobial stewardship Article bacteremia bacterial colonization blood culture clinical article cohort analysis controlled study drug use female graft recipient human male minimum inhibitory concentration overall survival retrospective study screening vancomycin resistant Enterococcus adolescent aged allotransplantation antimicrobial stewardship bacteremia cancer center Gram positive infection hematopoietic stem cell transplantation isolation and purification microbiology middle aged regression analysis vancomycin resistant Enterococcus Washington young adult
We examined vancomycin-resistant enterococci (VRE)-directed antimicrobial use and VRE bacteremia in a cohort of allogeneic hematopoietic cell transplantation patients from a center where VRE screening is standard prior to transplant. In this cohort, VRE bacteremia (VREB) was infrequent. In patients without VREB, colonized patients received VRE therapy more often than noncolonized patients. © 2018 by The Society for Healthcare Epidemiology of America. All rights reserved.

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